The Best Supplements for Estrogen Dominance

supplements for estrogen dominance

Top Supplements for Estrogen Dominance Relief

Estrogen and progesterone balance is key to a healthy reproductive system. But these hormones also affect many other processes in the body for women. And when there is too much estrogen or too little progesterone, estrogen dominance occurs.

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And if you are one of the many women struggling with estrogen dominance you know how destabilizing it is.

Estrogen dominance can disrupt your overall well-being, affecting everything from your mood to your menstrual cycle, weight, and more.

However, with the right supplements, you can rebalance your hormones and regain control of your health.

The best way to balance your hormones is always through a holistic approach through a healthy diet and a healthy lifestyle.

However, including supplements and herbal adaptogens is a great way to support hormonal balance and overcome estrogen balance.

So if you’re struggling with symptoms of hormonal imbalance, and high estrogen levels, this list of supplements for estrogen dominance may help you find balance.

From supporting healthy estrogen metabolism to detoxifying excess estrogen, these supplements can play a crucial role in providing relief from estrogen dominance.

supplements for estrogen dominance 1

What is Estrogen Dominance?

Estrogen dominance occurs when there is an imbalance between estrogen and progesterone levels in the body. 

This can occur during the hormonal shifts during perimenopause, but can also occur during other times as well.

The role of estrogen in the female body

Estrogen, often referred to as the primary female sex hormone, has many functions in the body that extend beyond reproductive functions.

Estrogen maintains bone health, cardiovascular function, brain function, skin health, and metabolism.

So maintaining balanced estrogen levels is essential for overall health and well-being in both men and women.

However, too much estrogen or estrogen imbalance causes health problems in both men and women. Men do produce some estrogen as well and when men have estrogen imbalance it causes issues such as gynecomastia, and impotence.

Symptoms of Estrogen Dominance

Common symptoms of estrogen dominance include:

  • Irregular menstrual periods
  • Worse PMS symptoms and painful periods 
  • Heavy or prolonged periods
  • Breast tenderness  
  • Decreased sex drive  
  • Mood swings and irritability
  • Weight gain

Causes of Estrogen Dominance

Several factors can contribute to estrogen dominance, including:

  • Exposure to environmental toxins and xenoestrogens 
  • Stress and high cortisol levels  
  • Poor liver function
  • Genetic factors
  • Poor gut health or leaky gut 

Exposure to environmental toxins and xenoestrogens can contribute to estrogen dominance by introducing external sources of estrogen-like compounds into the body, disrupting hormonal balance and leading to an excess of estrogen relative to progesterone.

These xenoestrogens, found in various substances like plastics, pesticides, and certain chemicals, mimic the effects of natural estrogen and can accumulate in the body over time, exacerbating estrogen dominance.

Chronic stress and high cortisol levels can also disrupt hormonal balance by diverting resources away from the production of progesterone and towards cortisol synthesis in the adrenal glands.

This imbalance can lead to a relative deficiency of progesterone compared to estrogen, resulting in estrogen dominance.

Poor liver function can impair the body’s ability to metabolize and eliminate excess estrogen effectively. The liver plays a crucial role in detoxification processes, including the breakdown and clearance of estrogen from the body.

When liver function is compromised due to factors like excessive alcohol consumption, a high intake of processed foods, or certain medications, estrogen metabolism may be impaired, contributing to estrogen dominance.

Genetic factors can predispose individuals to estrogen dominance by influencing hormone metabolism and receptor sensitivity.

Certain genetic variations may affect how efficiently the body metabolizes estrogen or how effectively cells respond to hormonal signals, potentially leading to imbalances in estrogen and progesterone levels.

Poor gut health or leaky gut can also contribute to estrogen dominance by disrupting the balance of gut bacteria and impairing the body’s ability to eliminate excess estrogen through the digestive tract.

A compromised gut lining, characterized by increased intestinal permeability, can allow toxins, including estrogen metabolites, to leak into the bloodstream, further exacerbating estrogen dominance.

Excess estrogen levels can disrupt the delicate balance of hormones in your body, leading to a variety of health problems.

In the next sections, we will explore the top supplements, lifestyle changes, and natural remedies that can help regulate estrogen levels and restore hormonal balance to alleviate symptoms of estrogen dominance.

Whether you’re experiencing mood swings, irregular periods, or other hormonal imbalances, there are effective solutions to support your health and well-being.

Diet and estrogen dominance

Before you try supplements for estrogen dominance, it is important to ensure you are also eating a diet rich in nutrients that assist in estrogen metabolism and detoxification processes.

That means eating foods rich in fiber, to help flush out estrogen. Include foods rich in vitamins and minerals including B vitamins and magnesium.

Foods rich in omega-3 fatty acids are essential for estrogen and hormone balance due to their antiinflammation properties.

Eating leafy greens is essential as they are rich in fiber, and b vitamins including folate.

One of the most important foods in estrogen detoxification is cruciferous vegetables. Here are the benefits of cruciferous vegetables for estrogen dominance.

Cruciferous Vegetables for Estrogen Metabolism

When it comes to supporting estrogen balance and promoting healthy estrogen metabolism, cruciferous vegetables are one of the best foods to eat for estrogen dominance.

These nutrient-packed veggies are known for their ability to aid in the regulation of hormones and overall hormonal balance.

Cruciferous vegetables are a family of plants that include broccoli, kale, cauliflower, Brussels sprouts, and cabbage.

They contain a compound called indole-3-carbinol (I3C) that helps in the metabolism of estrogen and supports healthy estrogen levels.

The I3C found in cruciferous vegetables enhances liver function, which is crucial for estrogen detoxification. It assists in breaking down estrogen into less potent forms, aiding in the removal of excess estrogen from the body.

Moreover, cruciferous vegetables also contain phytochemicals called glucosinolates. These compounds are responsible for the distinct aroma and taste of these vegetables.

Glucosinolates have been found to have anti-estrogenic properties, blocking the effects of excess estrogen in the body.

Adding cruciferous vegetables to your diet is a simple yet effective way to support hormonal balance and healthy estrogen metabolism.

These vegetables can be consumed raw, lightly steamed, or incorporated into various dishes like stir-fries, salads, or soups.

Here are some popular cruciferous vegetables to include in your meals:

  • Broccoli    
  • Kale   
  • Cauliflower  
  • Brussels sprouts
  • Cabbage

Supplements for estrogen dominance

Calcium D-Glucarate

One effective supplement for liver support is calcium D-glucarate. This compound aids in the detoxification process by inhibiting an enzyme called beta-glucuronidase.

Beta-glucuronidase can cause the reabsorption of estrogen by breaking down its conjugated form, leading to an imbalance. By taking calcium D-glucarate, you can promote the elimination of estrogen metabolites and enhance liver function.

Milk Thistle

Another beneficial supplement for liver support is milk thistleMilk thistle contains a potent antioxidant called silymarin, which has been shown to protect liver cells from damage and promote their regeneration.

Additionally, milk thistle supports the production of bile, the substance responsible for transporting toxins, including excess estrogen, out of the liver.

To enhance liver function and aid in the elimination of excess estrogen, consider incorporating calcium D-glucarate and milk thistle into your supplement regimen.

These natural compounds can support optimal liver health and help restore hormonal balance.

DIM Supplements for Hormonal Balance

DIM (diindolylmethane) supplements have gained popularity as one of the best supplements for estrogen dominance due to their ability to promote hormone balance especially the metabolism and clearance of estrogen.

DIM helps to promote the conversion of harmful estrogens into weaker forms, which can be easily eliminated.

A 2011 study found that DIM enhances estrogen metabolism and can be used as anti estrigenic dietary supplement in women at risk of developing thyroid proliferation disease.

This also indicates the role of excess estrogen in diseases including thyroid cancer in women which develops in women more often than men.

By enhancing the body’s ability to metabolize estrogen, DIM can help reduce the symptoms associated with estrogen dominance.

By regulating estrogen levels, DIM helps restore hormonal balance, which can alleviate symptoms such as bloating, mood swings, breast tenderness, and irregular periods, and even prevent some cancers liek breast and thyroid cancer in women.

Vitamin C

Vitamin C is known for its antioxidant properties, and it can help protect against oxidative stress caused by high estrogen levels.

High estrogen levels can lead to increased oxidative stress, which can damage cells and contribute to various health issues. Vitamin C, with its potent antioxidant properties, helps neutralize free radicals and reduce oxidative stress associated with high estrogen levels, supporting cellular health and reducing the risk of oxidative damage.

This nutrient also supports the health of estrogen receptors, ensuring their optimal function in the body.

Vitamin C has been shown to support estrogen receptor function, ensuring that estrogen signals are properly received and processed by the body. By enhancing estrogen receptor activity, vitamin C contributes to maintaining hormonal balance and overall health.

Furthermore, studies have shown that vitamin C may have potential benefits in reducing the risk of breast cancer, a condition often associated with estrogen dominance.

Vitamin C may offer potential benefits in reducing the risk of breast cancer by supporting healthy estrogen metabolism, enhancing immune function, and exerting anti-cancer properties.

Research suggests that adequate intake of vitamin C, either through diet or supplementation, may help lower the risk of developing breast cancer when part of a comprehensive approach to prevention.

Vitamin C can also help regulate menstrual cycles, making it beneficial for women experiencing irregular periods due to hormonal imbalances.

Estrogen plays a key role in regulating menstrual cycles, and vitamin C supports hormonal balance by promoting estrogen metabolism and the synthesis of other hormones such as progesterone, thus preventing an imbalance.

To incorporate more vitamin C into your diet, consider adding foods such as citrus fruits, strawberries, bell peppers, and broccoli to your meals.

Alternatively, you can also take vitamin C supplements under the guidance of a healthcare professional.

B vitamins

Eating B vitamin-rich foods is essential for maintaining hormonal balance. 

B vitamins, including vitamins B6, B9 (folate), and B12, are involved in various biochemical processes in the body, including hormone synthesis and metabolism.

These vitamins help convert food into energy and support the production of neurotransmitters that regulate hormone production including estrogen and progesterone.

Foods rich in B vitamins include leafy greens, whole grains, legumes, eggs, and lean meats.

Vitamin B6

Specifically, when it comese to estrogen balance vitamin B6, also known as pyridoxine, plays a crucial role in estrogen metabolism. Vitamin B6 helps convert estrogen into less potent forms, aiding in its elimination from the body.

Additionally, vitamin B6 supports liver function, which is essential for metabolizing estrogen effectively.

By promoting estrogen metabolism and liver health, vitamin B6 supplementation can help restore hormonal balance and alleviate symptoms of estrogen dominance.


Magnesium is involved in numerous biochemical reactions in the body, including those related to hormone regulation and metabolism.

Magnesium helps activate enzymes that facilitate estrogen metabolism, promoting the conversion of estrogen into its less potent forms for elimination.

Furthermore, magnesium has anti-inflammatory properties and can help reduce levels of cortisol, the stress hormone. Lowering cortisol levels can help mitigate the impact of stress-induced estrogen dominance.

By supporting estrogen metabolism and reducing inflammation and stress, magnesium supplementation can contribute to balancing hormone levels and alleviating symptoms of estrogen dominance.

Read related post: The best foods rich in magnesium.

Vitamin D

Vitamin D plays a crucial role in hormone regulation and immune function. It influences the activity of enzymes involved in estrogen metabolism and can help optimize hormonal balance.

Adequate vitamin D levels have been associated with improved estrogen metabolism and reduced risk of estrogen-related conditions such as breast cancer and endometriosis.

Additionally, vitamin D supports immune function and helps reduce inflammation, which can further support overall hormonal balance.

Supplementation with vitamin D may be beneficial for individuals with estrogen dominance, particularly those with low vitamin D levels, as it can help regulate estrogen metabolism and promote overall health.

However, don’t take vitamin D without the guidance of your healthcare provider. Too much vitamin D is toxic.

Read related post: Signs of vitamin D deficiency and why you may be deficient


Zinc is an essential mineral that plays a role in various physiological processes, including hormone production and metabolism.

Zinc is involved in the synthesis of progesterone, a hormone that counteracts the effects of estrogen and helps maintain hormonal balance.

Additionally, zinc helps regulate the activity of enzymes involved in estrogen metabolism, promoting the conversion of estrogen into less active forms.


Probiotics are beneficial bacteria that support gut health and immune function. A healthy gut microbiome is essential for optimal estrogen metabolism and elimination.

Probiotics help maintain a balanced gut microbiota, which plays a crucial role in regulating estrogen levels and reducing the risk of estrogen dominance.

Additionally, probiotics support immune function and help reduce inflammation, which can further support hormonal balance.

By promoting gut health and immune function, probiotic supplementation can help improve estrogen metabolism and reduce the risk of estrogen dominance.

There are many foods you can eat to nourish your gut bacteria such as kefir, kimchi, yogurt, and fiber-rich foods as they provide prebiotics.

But if you are not eating these foods often and suspect you may have a probiotic deficiency, a probiotic supplement is a great way to support your gut health and estrogen clearance.

Related post: Signs you need probiotics.

​Omega 3 Fatty acids

Omega-3 fatty acids, found primarily in fatty fish like salmon, mackerel, and sardines, have been studied for their potential role in modulating aromatase activity, an enzyme involved in estrogen synthesis. Aromatase converts androgens (male hormones) into estrogens, contributing to overall estrogen levels in the body.

Research suggests that omega-3 fatty acids may help inhibit aromatase activity, thereby reducing the conversion of androgens to estrogens.

By inhibiting aromatase, omega-3 fatty acids may help lower estrogen levels and mitigate estrogen dominance.

Additionally, omega-3 fatty acids possess anti-inflammatory properties, which can help reduce inflammation associated with estrogen dominance and support overall hormonal balance.


Sulforaphane, a powerful compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts, has garnered significant attention for its potential role in promoting estrogen balance and mitigating estrogen dominance.

Functions of sulforaphane in reducing estrogen balance:

Supports estrogen metabolism 

Sulforaphane influences estrogen metabolism by modulating the activity of enzymes involved in the breakdown of estrogen in the body.

Specifically, sulforaphane has been shown to enhance the activity of phase II detoxification enzymes, such as glutathione S-transferase (GST), which play a crucial role in conjugating and eliminating estrogen metabolites.

Anti-inflammatory and Antioxidant Properties

Sulforaphane exhibits potent anti-inflammatory and antioxidant properties, which can help mitigate inflammation and oxidative stress, both of which are associated with estrogen dominance.

Chronic inflammation and oxidative stress can disrupt estrogen metabolism and promote the proliferation of estrogen-sensitive tissues, contributing to estrogen dominance and associated health issues.

Detoxification Support

  • Estrogen dominance can arise from impaired detoxification pathways, particularly in the liver, where estrogen metabolites are processed and eliminated.
  • Sulforaphane supports liver function by inducing the expression of detoxification enzymes and enhancing the clearance of toxins and excess estrogen from the body.
  • By promoting liver detoxification pathways, sulforaphane helps maintain optimal estrogen metabolism and reduces the risk of estrogen dominance.

Regulation of Hormone Receptors

  • Sulforaphane has been shown to modulate the activity of estrogen receptors, which play a central role in mediating the effects of estrogen in the body.
  • Research suggests that sulforaphane may exert both estrogenic and anti-estrogenic effects, depending on the context and concentration, which can help restore balance to estrogen signaling pathways.
  • By regulating estrogen receptor activity, sulforaphane may help prevent excessive estrogenic stimulation and mitigate estrogen dominance.


Selenium aids in decreasing estrogen dominance primarily through its support of liver function and estrogen metabolism.

As a crucial cofactor for antioxidant enzymes and detoxification pathways in the liver, selenium enhances the body’s ability to metabolize and eliminate excess estrogen effectively. 

Since selenium promotes optimal liver function, it facilitates the clearance of estrogen metabolites from the body, helping to rebalance estrogen levels. 

Additionally, selenium’s anti-inflammatory properties contribute to reducing inflammation, which can be associated with estrogen dominance.

As always, its is best to get your nutrients from whole foods before trying supplemenation. However supplements can help close nutritional gaps.

Also some supplements such as natural herbs may not be something most people have as part of their diet. Please note too that you should always dconsult your health care provider before taking supplements.

Lifestyle Changes to Support Hormonal Balance

While supplements can be helpful, incorporating certain lifestyle changes can also contribute to maintaining hormonal balance.

 In this section, we will explore how personal care products, sun exposure for vitamin D synthesis, and hormonal contraceptives can impact estrogen levels and support overall hormone health.

1. Personal Care Products

Many personal care products such as cosmetics, skincare, and cleaning products contain chemicals that can disrupt hormone balance.

Look for products that are labeled “paraben-free” and “phthalate-free,” as these chemicals have been linked to hormone disruption. Choose natural alternatives whenever possible to reduce your exposure to potentially harmful substances.

2. Sun Exposure and Vitamin D

Vitamin D, often called the “sunshine vitamin,” plays a crucial role in hormone regulation. Spending time in the sun allows your body to naturally synthesize vitamin D, which is important for maintaining overall health, including hormonal balance. However, it’s essential to protect your skin from excessive sun exposure and always follow sun safety guidelines.

vitamin D

3. Hormonal Contraceptives

Birth control pills and other forms of hormonal contraceptives can impact estrogen levels in the body.

It’s important to discuss the potential effects of these medications on your hormone balance with your healthcare provider and discuss if there is an alternative birth control method they recommend.

4. Hormone Replacement Therapy (HRT)

Hormone replacement therapy (HRT) is commonly used to manage symptoms of menopause and other hormonal imbalances.

If you are considering HRT, it’s essential to have a thorough discussion with your healthcare provider to understand the potential benefits and risks associated with this treatment option.

Diet and nutrition

A high-fat and inflammatory diet can increase estrogen and cause estrogen dominance because fat cells produce estrogen as well.

So consider a healthy diet rich in natural foods to lower estrogen levels. Eating foods such as broccoli, and cabbage can help improve estrogen balance.  

Add probiotic-rich foods to your diet as well.

An often overlooked factor in hormonal balance is the health of our gut microbiome.

Research has shown a strong connection between the gut and hormonal health, with the gut microbiota influencing the production and metabolism of sex hormones.

To support a healthy gut microbiome, incorporating a diverse range of fiber-rich foods, fermented foods, and probiotic supplements can be beneficial.

Include foods like salmon and other sources of omega-3 three fatty acids to reduce inflammation. Many leafy greens are great sources of b vitamins and are also powerful antioxidants. 

Managing Stress and Hormonal Balance

Chronic stress can have a significant impact on our overall health, including hormone balance. When we experience stress, our body produces stress hormones that can disrupt the delicate equilibrium of our hormones, including those involved in regulating estrogen levels.

To maintain optimal hormonal balance and mitigate the effects of chronic stress, it is essential to take proactive steps in managing stress and supporting our body’s natural mechanisms for hormone regulation.

Implementing stress management techniques can also play a vital role in maintaining hormonal equilibrium.

Practices such as regular exercise, mindfulness meditation, deep breathing exercises, and engaging in activities that bring joy and relaxation can help reduce chronic stress levels and promote overall well-being.

Regulating Blood Sugar and Sex Hormones

Maintaining stable blood sugar levels is also crucial for hormone balance. Fluctuations in blood sugar can disrupt the delicate interplay between insulin, sex hormones, and other hormones involved in regulating our body’s functions.

To support stable blood sugar levels, it is recommended to consume balanced meals that include a combination of complex carbohydrates, healthy fats, and protein.

In conclusion, managing stress, supporting the gut microbiome, and ensuring adequate intake of B vitamins are all important factors in maintaining hormonal balance.


In conclusion, taking care of hormonal balance is essential for women’s health in the modern world. Estrogen dominance can cause various symptoms and impact overall well-being.

Fortunately, there are effective solutions available, including dietary supplements to help detox estrogen.

By incorporating the right supplements into your routine, you can support your body’s natural hormone regulation and alleviate stress on the female body.

These supplements are carefully formulated to address estrogen dominance and promote overall hormonal harmony.

Additionally, lifestyle changes such as reducing stress levels, adopting healthy eating habits, and using natural personal care products can also contribute to hormonal balance. 

Stress hormones can disrupt estrogen levels, so incorporating stress management techniques, like mindfulness and exercise, can be beneficial.

Remember to consult with a healthcare provider before starting any new supplement regimen or if you suspect you have a medical condition related to estrogen dominance.

They can provide personalized guidance and ensure that you find the best approach for your unique needs.

Prioritizing women’s health and seeking natural solutions will help them navigate the challenges of the modern world and maintain a balanced and vibrant life.

Supplements for estrogen dominance

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